Khảo sát kĩ thuật tạo hình xung lực bức xạ âm ARFI trong chẩn đoán hạt giáp

Ttudy the feasibility of acoustic radiation force impulse (ARFI) imaging in the diagnosis of thyroid nodules

summa ry

Purpose: To assess the feasibility of acoustic radiation force impulse (ARFI) imaging (VTQ and VTI) for differentiation of benign and malignant thyroid nodules.

Materials and methods: A total of 130 thyroid nodules underwent conventional ultrasound, including Color Doppler ultrasound using a 7.5MHz linear transducer; ARFI imaging was performed at 4MHz using Siemens Acuson S2000 B-mode- ARFI combination transducer; and FNAC (Fine needle aspiration cytology) assessment of thyroid nodule as reference criteria.

Results: 130 nodules were analysed. 103 nodules were benign, 23 nodules were malignant and 4 follicular lesions. The median velocity of ARFI imaging in the normal nodule-free thyroid gland, as well as benign and malignant thyroid nodules was 1.41m/s (range 0.84 - 3m/s); 2.15m/s (range 0.8 - 4.04m/s) and 3.2m/s (range 0.9 - 9.22m/s), respectively. At cut-off 2.16m/s, a sensibility of 79.4% and specificity of 53.7% of VTQ could be achieved (AUROC = 0.731). The difference between VTQ of normal thyroid tissue and thyroid nodule (benign, malignant) has the sensibility of 79.5% and specificity of 51% at the cut-off of 0.63 (AUROC = 0.72). A significant difference was found between VTI on the one hand and benign or malignant thyroid nodules on the other hand, a = 0.001.

Conclusions: VTQ and VTI of ARFI can be useful in the assessment of benign and malignant thyroid nodules. These novel quantitative and qualitative elastography method should be combined to give a more reliable result. Further investigations are needed to compare these baseline findings in thyroid nodules in healthy thyroid tissue with those in thyroid diffuse diseases.