Khản năng sản xuất 177Lu từ bia Lutetium tự nhiên trên lò phản ứng hạt nhân Đà Lạt

Production ability of 177Lu from natural lutetium target on the Da Lat nuclear reactor

SUMMARY

177Lu is presently being considered as a potential radionuclide, for use in in-vivo targeted radiotherapy, owing to its favorable nuclear decay characteristics. This paper presents some research fi ndings on the ability to produce 177Lu on the IVV-9 research reactor with thermal neutron fl ux of 1.8×1013.cm-2.s-1 at the Nuclear Research Institute to produce this radioactive isotope. Our products have specifi c activity of 17.7 mCi/mg Lu, radionuclide and radiochemical purities more than 99.9% of total radioactivity. Immediate products are used for the initial basic research of labeling capabilities with DOTATATE, and especially studying on the possibility preparing 177Lu-EDTMP used to treat pain palliation caused by bone metastases.

Keywords: production of Lu-177, nuclear reactor IVV-9, 177Lu-EDTMP, pain palliation.