Điều chế Phosphorus-32 (P-32) từ bia chiếu xạ p2o5 cho mục đích điều trị trong y học hạt nhân

Preparation of phosphorus-32 (p-32) from irradiated target p2o5 for therapeutic purposes in nuclear medicine

SUMMARY

Phosphorus-32 is produced using the nuclear reaction 31P (n,γ) 32P by irradiation of the phosphorus peroxide (P2O5) target. Phosphoric acid is prepared by the dissolution of irradiated target in 40 ml of boiling chloric acid 0,1 N. When the dissolution of phosphor peroxide is completed, the beaker is allowed to cool. 8 ml of 30% H2O2 is added and refl uxed for 3h. Finally, the solution is fi ltered through a sintered glass fi lter, porosity G3 and passed into a column of cationic exchanger (Dowex-50 W-X4 preconditioned in hydrogen form) to remove metallic impurities. The effl uent is collected as the stock solution.

Radiochemical purity is determined by paper chromatography (radiochemical purity control) in the solvent system: Whatman No. 1 paper and the mixture of isopropyl alcohol : water : 50% trichloracetic acid : 25% NH4OH (75:15:10:0.3 v/v.) as a mobile phase, developing time ranged from 12 to 17 h.

Radiochemical purity of phosphoric acid (H3 32PO4) solution prepared by our method is obtained more than 99%.

Key word: H3 32PO4, Phosphorus-32.