• Thứ 4, 03/06/2020
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Nhận xét kết quả bước đầu vai trò của f-18 fdg pet/ct trong phát hiện vị trí tổn thương ở bệnh nhân ung thư chưa rõ nguyên phát tại Bệnh viện K

Nhận xét kết quả bước đầu vai trò của f-18 fdg pet/ct trong phát hiện vị trí tổn thương ở bệnh nhân ung thư chưa rõ nguyên phát tại Bệnh viện K

12/18/2019 14:29:08 | 0 binh luận

Remarking the first step results of the role of f-18 fdg pet/ct in determining the positive position in the unknow cancer in the cancer national Hospital

SUMMARY

Carcinoma of unknown primary tumors (CUP) is present in 2% of all patients with malignant neoplasms. However, only 20% - 73% of primary sites are identified before the patients die. Currently, F-18 FDG PET/CT is widely used for the diagnosis of CUP. The objective of this study was to evaluate the role of F-18 FDG PET / CT in these patients.

Results: 30 patients with unclear cancers were treated with F-18 FDG PET / CT, the mean age of patients was 53.6 ± 9.7. There were 18/30 patients (60%) who were diagnosed with cancer. PET / CT (compared with pathology), the rest is false 12/30 BN (40%). Localized nodal metastases is an area of the neck. The most common pathological anomalies were squamous cell carcinoma (56.7%), adenocarcinoma (16.7%) and noncancerous cancers (26.7%).

Conclusion: F-18 FDG PET / CT is a useful method for detecting primary malignant sites in patients with primary tumors.

Ứng dụng lâm sàng PET/CT sử dụng dược chất phóng xạ không phải 18F-FDG trong ung thư

Ứng dụng lâm sàng PET/CT sử dụng dược chất phóng xạ không phải 18F-FDG trong ung thư

03/31/2020 13:59:54 | 0 binh luận

Clinical Non-FDG PET/CT Applications in Oncology

SUMMARY

In clinical practice 18FDG-PET is applied in almost cancers in staging, re-staging, monitoring therapy response and the follow-up. On the other hand, at no time do all tumors show significant increase of 18FDG uptake on PET imaging. Particularly in prostate cancer, neuroendocrine and hepatocellular carcinoma... In this review we have introduced those already used for clinical applications like 11C- and 18F-Choline, 11C-Methionine and 18F-FET, 18F-DOPA, 68Ga-DOTA-somatostatine analogues, 11C-acetate and 18F-FLT. Choline has indicated a high affinity for prostate cancer, even if low grade being labelled with either 11C or 18F, the former being the preference by dint of lower urinary excretion and patients exposure. The latter is more beneficial for centers without on-site cyclotron. Methionine is required for protein synthesis and tumor cells which have been used for imaging of CNS neoplasms. NET tumors demonstrate an increased activity of L-DOPA decarboxylase, hence high uptake of 18FDOPA. 18F-FLT is a specific marker in application of FLT is lung cancer. Other tracers are used in PET utilized include 18F-MISO, 64Cu- ATSM, 18F-EF5, which highlight the presence of hypoxic areas are useful for radiotherapy.

Key words: radiopharmaceuticals, choline, methionine, DOPA, DOTA, FLT.

Đo độ tập trung Flouro-Deoxy-Glucose (FDG) ở bệnh nhân ung thư thực quản

Đo độ tập trung Flouro-Deoxy-Glucose (FDG) ở bệnh nhân ung thư thực quản

03/31/2020 13:40:18 | 0 binh luận

Standardized Uptake Value of Glucose on PET/CT scan of esophageal cancer patients

summa ry

Standardized Uptake Value (SUV) was determined for 100 esophageal cancer patients on PET/CT. SUV in primary tumors of esophageal cancer was 10.7±5.0; higher than in mediastinal lymph nodes 7.1±0.9; supraclavicular lymph nodes, 6.2±2.5; abdominal lymph nodes 6.9±2.5; metastases of bone 8.0±4.1; lung 3.3±1.7 and liver 7.2±2.6. SUV Index increased proportionally to tumor size, lymph nodes, stage of disease.

Ghi hình phóng xạ 99mTc-MIBI đánh giá đáp ứng với xạ trị ở bệnh nhân ung thư phổi không tế bào nhỏ

Ghi hình phóng xạ 99mTc-MIBI đánh giá đáp ứng với xạ trị ở bệnh nhân ung thư phổi không tế bào nhỏ

03/31/2020 13:31:33 | 0 binh luận

The role of 99mTc-MIBI SPECT in the assesstment of radiotherapy response in patients with non-small cell lung cancer

summa ry

48 patients with non-small cell lung cancer underwent a 9mTc-MIBI SPECT studies before starting and after radiotherapy 4-5 weeks. The results indicate that this method is valuable coordinate with CT in evaluation of response to radiotherapy. 99mTc-MIBI SPECT imaging may be useful to differentiate between necrotic tumor tissue and residual, recurrent lung lesions after radiot

Key words: 99mTc-MIBI SPECT scan, non-small cell lung cancer.

Dự báo biến chứng chảy máu trong ổ nhồi máu bằng chỉ số thấm hàng rào máu não trên chụp cắt lớp vi tính tưới máu ở bệnh nhân thiếu máu cục bộ não cấp tính

Dự báo biến chứng chảy máu trong ổ nhồi máu bằng chỉ số thấm hàng rào máu não trên chụp cắt lớp vi tính tưới máu ở bệnh nhân thiếu máu cục bộ não cấp tính

04/03/2020 11:22:47 | 0 binh luận

Prediction intra- infarct hemorrhage by blood brain barrier indice on perfusion CT scanner in acute ischemic stroke patient

summa ry

Background: Haemorrhagic transformation is the leading cause of early neurological deterioration in patients with acute ischaemic stroke. Early prediction of this complication is important for selecting appropriate treatment methods, preventing and planning for the complication. Existing predictors of haemorrhagic transformation remain limitations in prognosis accuracy, clinical practicality and radiation safety. The aim of this study is assess the role of blood-brain barrier permeability in prediction of haemorrhagic transformation.

Methods: Blood-brain barrier permeanility was obtained using perfusion CT data with implication of the Gjedde-Patlak plot. The obtained permeability value was used to predict occurrence of haemorrhagic transformation.

Results: mean blood-brain barrier permeability in lesions developed haemorrhagic transformation was found significantly higher than the value obtained in the lesion without complications. There were a significant relationship between increased permeability and occurence of haemorrhagic transformation. The threshold of 2.7ml/100g/min was established, above that stroke patients are at high risk of having haemorrhagic transfomation.

Conclusion: Increased blood-brain barrier permeability is onf of the factor related to haemorrhagic transformation in patients with acute ischaemic stroke. The perfusion CT obtained permeability is proven as a predictor of haemorrhagic transformation. Together with other clinical and imaging findings, pattern of blood-brain barrier permeability is recommended to be included into initial perfusion CT analysis. This may improve prediction, prevention and planning for medical nanagement in patients with acute ischaemic stroke.

Điều chế Phosphorus-32 (P-32) từ bia chiếu xạ p2o5 cho mục đích điều trị trong y học hạt nhân

Điều chế Phosphorus-32 (P-32) từ bia chiếu xạ p2o5 cho mục đích điều trị trong y học hạt nhân

04/03/2020 10:59:25 | 0 binh luận

Preparation of phosphorus-32 (p-32) from irradiated target p2o5 for therapeutic purposes in nuclear medicine

SUMMARY

Phosphorus-32 is produced using the nuclear reaction 31P (n,γ) 32P by irradiation of the phosphorus peroxide (P2O5) target. Phosphoric acid is prepared by the dissolution of irradiated target in 40 ml of boiling chloric acid 0,1 N. When the dissolution of phosphor peroxide is completed, the beaker is allowed to cool. 8 ml of 30% H2O2 is added and refl uxed for 3h. Finally, the solution is fi ltered through a sintered glass fi lter, porosity G3 and passed into a column of cationic exchanger (Dowex-50 W-X4 preconditioned in hydrogen form) to remove metallic impurities. The effl uent is collected as the stock solution.

Radiochemical purity is determined by paper chromatography (radiochemical purity control) in the solvent system: Whatman No. 1 paper and the mixture of isopropyl alcohol : water : 50% trichloracetic acid : 25% NH4OH (75:15:10:0.3 v/v.) as a mobile phase, developing time ranged from 12 to 17 h.

Radiochemical purity of phosphoric acid (H3 32PO4) solution prepared by our method is obtained more than 99%.

Key word: H3 32PO4, Phosphorus-32.

Khản năng sản xuất 177Lu từ bia Lutetium tự nhiên trên lò phản ứng hạt nhân Đà Lạt

Khản năng sản xuất 177Lu từ bia Lutetium tự nhiên trên lò phản ứng hạt nhân Đà Lạt

04/03/2020 10:55:14 | 0 binh luận

Production ability of 177Lu from natural lutetium target on the Da Lat nuclear reactor

SUMMARY

177Lu is presently being considered as a potential radionuclide, for use in in-vivo targeted radiotherapy, owing to its favorable nuclear decay characteristics. This paper presents some research fi ndings on the ability to produce 177Lu on the IVV-9 research reactor with thermal neutron fl ux of 1.8×1013.cm-2.s-1 at the Nuclear Research Institute to produce this radioactive isotope. Our products have specifi c activity of 17.7 mCi/mg Lu, radionuclide and radiochemical purities more than 99.9% of total radioactivity. Immediate products are used for the initial basic research of labeling capabilities with DOTATATE, and especially studying on the possibility preparing 177Lu-EDTMP used to treat pain palliation caused by bone metastases.

Keywords: production of Lu-177, nuclear reactor IVV-9, 177Lu-EDTMP, pain palliation.

Ứng dụng kĩ thuật chụp PET/CT mô phỏng lập kế hoạch xạ trị ung thư

Ứng dụng kĩ thuật chụp PET/CT mô phỏng lập kế hoạch xạ trị ung thư

04/12/2020 21:31:25 | 0 binh luận

Application of PET/CT images for simulation in Radiation therapy planning

SUMMARY

Background: Application of PET/CT images for simulation in Radiation therapy planning is one of the most advantage techniques in cancer treatment. In 2009, Nuclear Medicine and Oncology Center of Bach Mai Hospital was the fi rst place in Vietnam, where PET/CT simulation for radiation therapy planning has been conducted successfully for cancer patients.

Objective: To build the PET/CT simulation process in radiation treatment planning for esophageal cancer. Subjects and methods: 50 esophageal cancer patients treated by radiation.

Results: Simulation for radiotherapy in esophageal cancer: PET/CT has higher values than CT such as detecting lesions more precisely and more clearly. Patients in our study had good response and less complication: overall response (complete and partial) with improving clinical symptoms: 80%, size of tumor reduced in 83% patients. Common complication is depletion (in 34% patients). Most complications are mild and can be treated by medicine.

Conclusion: Nuclear Medicine and Oncology Center Bach Mai Hospital has standardized the PET/CT simulation process for esophageal cancer patients with initial good results.

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